“when we hit perimenopause, it starts to fluctuate, and so ovulation becomes unpredictable and even then, we ovulate, and then another month we don’t ovulate, and so it becomes unreliable as well. this hormone conversion is not happening as it should,” said franco. “so, when that happens, it’s like we don’t get our natural prescription of anti-anxiety medication.”
that’s just one hormone. estrogen is also changing and shifting during perimenopause, too, fluctuating even more so than progesterone.
“estrogen is mostly related to the control centre of your emotions, how you’re able to control your emotions, but it also helps with memory, it helps with concentration and focus,” said franco.
during perimenopause, estrogen regulation takes a serious hit, rising to incredibly high levels before taking deep dives into severely low territory, making it just as unpredictable. during the menstrual cycle, your body is typically already equipped to cope with the changes, with both your body and brain helping stabilize your mood. but when perimenopause hits, the body has to find other ways to deal.
“it tries to compensate [for the loss of estrogen],” said franco. “so, it creates this other pathway to try and create other changes in your receptors to be able to cope with that mechanism, but it doesn’t work as well. it’s like if you have a thermostat in your house and it doesn’t read the temperature correctly. so, sometimes it works well, sometimes it doesn’t, and that’s why we hear a lot of patients going through perimenopause say, ‘it’s weird, because one week i feel great, i feel the most amazing, and then the next week i feel awful. i can’t get out of bed. i don’t recognize myself.’”
because it fluctuates so much, keeping up with those changes at a physiological level is a serious challenge.